INVESTIGATION OF DRUG CARRIER SYSTEMS WITH CONTROLLED AND PROGRAMMED DRUG RELEASE

 

 

 

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Drug carrier systems are critical in pharmacology, just as studying the drugs themselves. It is thus essential to promote a controlled and programmed drug release for the body. Controlling and programming the release of the drug is vital as it prolongs drug delivery and maintains the blood concentrations within the accepted therapeutic limits. Therefore, a drug delivery system affects the pharmacological activities by varying its release from the carrier. It is thus crucial to incorporate a drug carrier system to enhance a higher efficacy with a reduced or minimal side effect on the users’ body. It has several advantages to the patients, such as improved patient compliance (Rekha & , 2017). Improved patient compliance mainly arises because of a reduced frequency of administering a drug. Some of the patients may feel disappointed taking drugs often, especially when the dose goes for a longer time, for example, weeks or months, and may sometimes fail to adhere to the dose. With a reduced frequency of administering the drugs, the patients find it easy to take them as prescribed, thus boosting their compliance.  This paper will investigate drug carriers with a controlled and programmed drug release.

LITERATURE REVIEW

Microchip Controlled Reservoirs

The controlled release reservoirs with microchips have a vast potential for regulating the release of drugs. It has the properties that enable it to incorporate the modalities within each of the reservoirs and control the specific pulse of releasing the drug (Emerich & , 2007). The chip is comprised of a silicon wafer that has 34 reservoirs. Each of the reservoirs a volume of 25nl and has a gold membrane seal anode of 300nm in its thickness. A drug is delivered from the reservoirs when a current is applied between the embedded cathode and the gold membrane. The chip is still in its earlier stages though it has exhibited incredible results and is only projected to improve the outcomes with more modifications. It has delivered auspicious results due to its continued development and the fluorescent tracers (Emerich & , 2007).

Materials for the controlled drug release

For a controlled drug release, ceramics and glass materials have unique properties, making them the best materials for drug carriers. The properties of glass and ceramics that enable them to be used are due to their chemical and thermal resistance, particularly in strong alkaline and acidic environments. This helps to prevent the degradation of active drug ingredients. Furthermore, the ceramics and glass materials do not react with solvents, thus offering a gastric resistance that most polymers are likely susceptible to. Therefore, it opens new delivery routes, for example, targeted enteral delivery.

METHODOLOGY

Methods of Data Collection

The data for this research study will be obtained from a cross-sectional study of a selected area/hospital and its pharmacological tools. They will entail the use of questionnaires and interviews with the management and the chosen hospital’s pharmacists. The interview will cover the areas of concern of controlled and programmed drug release, such as the materials used and their reliability. Furthermore, it will emphasize the effectiveness of microchip controlled reservoirs as a controlled drug release mechanism in pharmacology. The questionnaires adopted will be self-administered and contain open-ended questions which the respondents can comfortably answer. The tactic will employ the use of paper questionnaires in this research.

Data Analysis.

Analyzing the collected data will entail deductive and inductive analysis. The inductive process shall aim to remove biases arising and develop any overarching impressions in the data collected. SPSS will be adopted in analyzing the data collected by questionnaires. Both the non-parametric and the parametric methods will be applied in analyzing the data collected.

 

 

References

Emerich, D. F. & C. H., 2007. Controlled Drug Release: Nanotechnology’s Impact on Cell Transplantation. Science Direct.

Rekha, M. & C. P. S., 2017. Drug Carriere: Nanoparticle Mediated Oral Delivery of Peptides and Proteins. Science Direct.